In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt

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In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt

AIM Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO(2)) in a simulated in vitro cornea inflammation environment. METHODS Lipopolysaccharide-stimulated cytokine secretions were evalua...

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Application of Graphene as Candidate Biomaterial for Synthetic Keratoprosthesis Skirt.

PURPOSE Synthetic keratoprostheses are required for visual rehabilitation in patients with end-stage corneal blindness. This study aimed to assess the biocompatibility of graphene material and its potential as a novel synthetic keratoprosthesis skirt material for corneal tissue engineering. METHODS Human corneal stromal fibroblasts were cultured on material surfaces including pristine graphen...

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Bioactive composite for keratoprosthesis skirt.

In this study, the fabrication and properties of a synthetic keratoprosthesis skirt for use in osteo-odonto-keratoprosthesis (OOKP) surgery are discussed. In the search for a new material concept, bioactive glass and polymethyl methacrylate (PMMA)-based composites were prepared. Three different bioactive glasses (i.e. 45S5, S53P4 and 1-98) and one slowly resorbing glass, FL107, with two differe...

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[Keratoprosthesis in cornea and ocular surface diseases].

In 1771, Guillaume Pellier de Quengsy,1 an ophthalmologist, proposed for the first time the possibility of substituting opacifie corneal tissue by “an artificial cornea”. The proposal was for transparent glass plates to substitute the opaque cornea in order to enhance the transparency of optic media. Improvements in topical and systemic immunosuppression and limbus transplant techniques for tre...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 2012

ISSN: 0007-1161,1468-2079

DOI: 10.1136/bjophthalmol-2012-301633